Apocalypse how: Your guide to handicapping the end of the world
Method of destruction: Global pandemic
How that's going to work: One test monkey gets loose from a laboratory with the World's Most Deadly Pathogen™ swimming around in its guts. It bites a dog, the dog bites its owner, and pretty soon everyone is coughing up blood and dropping dead. By the time the guys in the NBC containment suits show up, dozen of people have already left the area and it's impossible to contain. Within weeks, everyone is dead, apart from a handful of survivors who start heading toward either Boulder or Las Vegas -- depending on whether they are good or evil -- to prepare for a final apocalyptic battle.
What it's going to look like:
Why that probably won't happen: Remember what a letdown H1N1 was? Apocalyptic pestilence is way overrated.
Odds: 12 to 1